Tumor
Collier's New Encyclopedia (1921)
in surgery, any morbid parasitic growth, generally, though not always, attended by swelling. Tumors are primarily divided into two classes, the first innocent, including non-malignant, solid, benign, or sarcomatous, and the second malignant growths. Tumors of the first type occur in comparatively few tissues, and do not alter the adjacent parts unless the tumor produces pressure and partial inflammation; they have no tendency to ulcerate or slough, and, if extirpated by a surgical operation, they do not grow again. They vary considerably in structure, being fatty, cellular, fibrous, fibroid or tendonous, encysted, vascular, cartilaginous, osseous, or fibro-cartilaginous. Fatty and cartilaginous tumors often reach a size so large that they weigh many pounds. They should be excised while they are small. A tumor of the second type, on the contrary, may arise in almost any part of the body, though some parts are more liable than others to attacks. They tend to propagate their morbid action to the adjacent parts, or, by means of the blood, even to spots remote from their formative seat; they ulcerate or slough, and, when extirpated by surgical operation, grow again, either at the original or some other place. The cancer and tubercle are leading types of malignant tumors. A third type of tumor, the semi-malignant, is intermediate between the first two, and includes some forms of sarcomic and of melanotic tumor, the painful subcutaneous tumor or tubercle, nævi, polypi, etc. Melanosis is commoner in horses than in the human subject, and chiefly in white or gray horses. Various tumors are inter-thoracic, affecting the heart, the lungs, etc. There are also tumors of the brain, of the liver, the rectum, etc.; and in women the uterus and the vagina are specially liable to be affected with tumor.
What Has Changed in the Last Century
Collier's in 1921 called a tumour "any morbid parasitic growth" and sorted growths by their texture — fatty, fibrous, osseous, cartilaginous — with surgery the only real remedy: "they should be excised while they are small." Since then tumours have been redefined as diseases of the cell's own genome, driven by mutations in genes such as those found from the 1970s onward, and they are classified by cell of origin and molecular markers rather than by consistency. Treatment expanded far beyond the knife: radiotherapy, chemotherapy from the 1940s, targeted drugs such as imatinib approved in 2001, and immune checkpoint inhibitors from 2011. Two details in the old scheme are now plainly wrong: the "tubercle" is tuberculosis, a bacterial infection, not a malignant tumour, and sarcoma is malignant, not one of the "innocent" growths; the intermediate "semi-malignant" class has been dropped, though polyps and moles are indeed recognised as precursors of cancer.
Written for this edition, 2026.